Synergism between 5-fluorouracil and oxanosine in inhibiting growth of ras-expressed cells in vitro and in vivo.

5-FU=4.6). Another pair ofras+ cells and ras~ cells, i.e., K-ras NIH/3T3 and NIH/3T3, respectively, gave a similar result. The effect of the two drugs in combination2* on ras+ cells was synergistic as shown in Fig. 1. Their effect in combination on ras~ cells was rather additive. In all these experiments, cells were cultured with a drug (or drugs) for 2 days without changing the mediumand cell growth was then determined (a 48-hour-exposure). Next, we